Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

Oriane Duchamp de Lageneste, Anaïs Julien, Rana Abou-Khalil, Giulia Frangi, Caroline Carvalho, Nicolas Cagnard, Corinne Cordier, Simon J. Conway and Céline Colnot ()
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Oriane Duchamp de Lageneste: Paris Descartes University
Anaïs Julien: Paris Descartes University
Rana Abou-Khalil: Paris Descartes University
Giulia Frangi: Paris Descartes University
Caroline Carvalho: Paris Descartes University
Nicolas Cagnard: Paris-Descartes Bioinformatics Platform
Corinne Cordier: Paris Descartes University
Simon J. Conway: Indiana University School of Medicine
Céline Colnot: Paris Descartes University

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain poorly characterized. Here, we show that periosteum contains SSCs with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells (BMSCs) in mice. Although periosteal cells (PCs) and BMSCs are derived from a common embryonic mesenchymal lineage, postnatally PCs exhibit greater clonogenicity, growth and differentiation capacity than BMSCs. During bone repair, PCs can efficiently contribute to cartilage and bone, and integrate long-term after transplantation. Molecular profiling uncovers genes encoding Periostin and other extracellular matrix molecules associated with the enhanced response to injury of PCs. Periostin gene deletion impairs PC functions and fracture consolidation. Periostin-deficient periosteum cannot reconstitute a pool of PCs after injury demonstrating the presence of SSCs within periosteum and the requirement of Periostin in maintaining this pool. Overall our results highlight the importance of analyzing periosteum and PCs to understand bone phenotypes.

Date: 2018
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DOI: 10.1038/s41467-018-03124-z

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