Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere

Jônatas Abrahão, Lorena Silva, Ludmila Santos Silva, Jacques Yaacoub Bou Khalil, Rodrigo Rodrigues, Thalita Arantes, Felipe Assis, Paulo Boratto, Miguel Andrade, Erna Geessien Kroon, Bergmann Ribeiro, Ivan Bergier, Herve Seligmann, Eric Ghigo, Philippe Colson, Anthony Levasseur, Guido Kroemer, Didier Raoult () and Bernard La Scola ()
Additional contact information
Jônatas Abrahão: IHU-Méditerranee Infection
Lorena Silva: IHU-Méditerranee Infection
Ludmila Santos Silva: IHU-Méditerranee Infection
Jacques Yaacoub Bou Khalil: CNRS
Rodrigo Rodrigues: Universidade Federal de Minas Gerais
Thalita Arantes: Universidade Federal de Minas Gerais
Felipe Assis: Universidade Federal de Minas Gerais
Paulo Boratto: Universidade Federal de Minas Gerais
Miguel Andrade: Universidade de Brasília, Asa Norte
Erna Geessien Kroon: Universidade Federal de Minas Gerais
Bergmann Ribeiro: Universidade de Brasília, Asa Norte
Ivan Bergier: Embrapa Pantanal
Herve Seligmann: IHU-Méditerranee Infection
Eric Ghigo: IHU-Méditerranee Infection
Philippe Colson: IHU-Méditerranee Infection
Anthony Levasseur: IHU-Méditerranee Infection
Guido Kroemer: Gustave Roussy Cancer Campus
Didier Raoult: IHU-Méditerranee Infection
Bernard La Scola: IHU-Méditerranee Infection

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44–1.51 Mb linear double-strand DNA coding for 1276–1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.

Date: 2018
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DOI: 10.1038/s41467-018-03168-1

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