Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Jayaram Vijayakrishnan, James Studd, Peter Broderick, Ben Kinnersley, Amy Holroyd, Philip J. Law, Rajiv Kumar, James M. Allan, Christine J. Harrison, Anthony V. Moorman, Ajay Vora, Eve Roman, Sivaramakrishna Rachakonda, Sally E. Kinsey, Eamonn Sheridan, Pamela D. Thompson, Julie A. Irving, Rolf Koehler, Per Hoffmann, Markus M. Nöthen, Stefanie Heilmann-Heimbach, Karl-Heinz Jöckel, Douglas F. Easton, Paul D. P. Pharaoh, Alison M. Dunning, Julian Peto, Frederico Canzian, Anthony Swerdlow, Rosalind A. Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Mel Greaves, Martin Zimmerman, Claus R. Bartram, Martin Schrappe, Martin Stanulla, Kari Hemminki and Richard S. Houlston ()
Additional contact information
Jayaram Vijayakrishnan: The Institute of Cancer Research
James Studd: The Institute of Cancer Research
Peter Broderick: The Institute of Cancer Research
Ben Kinnersley: The Institute of Cancer Research
Amy Holroyd: The Institute of Cancer Research
Philip J. Law: The Institute of Cancer Research
Rajiv Kumar: German Cancer Research Centre
James M. Allan: Newcastle University
Christine J. Harrison: Newcastle University
Anthony V. Moorman: Newcastle University
Ajay Vora: Great Ormond Street Hospital
Eve Roman: University of York
Sivaramakrishna Rachakonda: German Cancer Research Centre
Sally E. Kinsey: Leeds General Infirmary
Eamonn Sheridan: University of Leeds
Pamela D. Thompson: St. Mary’s Hospital
Julie A. Irving: Newcastle University
Rolf Koehler: University of Heidelberg
Per Hoffmann: University of Bonn
Markus M. Nöthen: University of Bonn
Stefanie Heilmann-Heimbach: University of Bonn
Karl-Heinz Jöckel: University of Duisburg–Essen
Douglas F. Easton: University of Cambridge
Paul D. P. Pharaoh: University of Cambridge
Alison M. Dunning: University of Cambridge, Strangeways Laboratory
Julian Peto: London School of Hygiene and Tropical Medicine
Frederico Canzian: German Cancer Research Center (DKFZ)
Anthony Swerdlow: The Institute of Cancer Research
Rosalind A. Eeles: The Institute of Cancer Research
ZSofia Kote-Jarai: The Institute of Cancer Research
Kenneth Muir: University of Manchester
Nora Pashayan: University of Cambridge
Mel Greaves: Institute of Cancer Research
Martin Zimmerman: Hannover Medical School
Claus R. Bartram: University of Heidelberg
Martin Schrappe: University Hospital Schleswig-Holstein
Martin Stanulla: Hannover Medical School
Kari Hemminki: German Cancer Research Centre
Richard S. Houlston: The Institute of Cancer Research

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10−9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10−8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.

Date: 2018
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DOI: 10.1038/s41467-018-03178-z

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