Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria

Thomas Hoffmann, Daniel Krug, Nisa Bozkurt, Srikanth Duddela, Rolf Jansen, Ronald Garcia, Klaus Gerth, Heinrich Steinmetz and Rolf Müller ()
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Thomas Hoffmann: Saarland University
Daniel Krug: Saarland University
Nisa Bozkurt: Saarland University
Srikanth Duddela: Saarland University
Rolf Jansen: Helmholtz Centre for Infection Research (HZI), Department of Microbial Drugs
Ronald Garcia: Saarland University
Klaus Gerth: Helmholtz Centre for Infection Research (HZI), Department of Microbial Drugs
Heinrich Steinmetz: Helmholtz Centre for Infection Research (HZI), Department of Microbial Drugs
Rolf Müller: Saarland University

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract Some bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias and limited analytical data sets. Here we perform a systematic metabolite survey of ~2300 bacterial strains of the order Myxococcales, a well-established source of natural products, using mass spectrometry. Our analysis encompasses both known and previously unidentified metabolites detected under laboratory cultivation conditions, thereby enabling large-scale comparison of production profiles in relation to myxobacterial taxonomy. We find a correlation between taxonomic distance and the production of distinct secondary metabolite families, further supporting the idea that the chances of discovering novel metabolites are greater by examining strains from new genera rather than additional representatives within the same genus. In addition, we report the discovery and structure elucidation of rowithocin, a myxobacterial secondary metabolite featuring an uncommon phosphorylated polyketide scaffold.

Date: 2018
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DOI: 10.1038/s41467-018-03184-1

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