Nanowire arrays restore vision in blind mice

Jing Tang, Nan Qin, Yan Chong, Yupu Diao, Yiliguma, Zhexuan Wang, Tian Xue, Min Jiang, Jiayi Zhang () and Gengfeng Zheng ()
Additional contact information
Jing Tang: Fudan University
Nan Qin: Fudan University
Yan Chong: Fudan University
Yupu Diao: Fudan University
Yiliguma: Fudan University
Zhexuan Wang: Fudan University
Tian Xue: University of Science and Technology of China
Min Jiang: Fudan University
Jiayi Zhang: Fudan University
Gengfeng Zheng: Fudan University

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 µm. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.

Date: 2018
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DOI: 10.1038/s41467-018-03212-0

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