Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis

Nuria Ferrandiz, Consuelo Barroso, Oana Telecan, Nan Shao, Hyun-Min Kim, Sarah Testori, Peter Faull, Pedro Cutillas, Ambrosius P. Snijders, Monica P. Colaiácovo and Enrique Martinez-Perez ()
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Nuria Ferrandiz: Imperial College London
Consuelo Barroso: Imperial College London
Oana Telecan: Imperial College London
Nan Shao: Imperial College London
Hyun-Min Kim: Harvard Medical School
Sarah Testori: Imperial College London
Peter Faull: Imperial College London
Pedro Cutillas: Imperial College London
Ambrosius P. Snijders: Imperial College London
Monica P. Colaiácovo: Harvard Medical School
Enrique Martinez-Perez: Imperial College London

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract The formation of haploid gametes from diploid germ cells requires the regulated two-step release of sister chromatid cohesion (SCC) during the meiotic divisions. Here, we show that phosphorylation of cohesin subunit REC-8 by Aurora B promotes SCC release at anaphase I onset in C. elegans oocytes. Aurora B loading to chromatin displaying Haspin-mediated H3 T3 phosphorylation induces spatially restricted REC-8 phosphorylation, preventing full SCC release during anaphase I. H3 T3 phosphorylation is locally antagonized by protein phosphatase 1, which is recruited to chromosomes by HTP-1/2 and LAB-1. Mutating the N terminus of HTP-1 causes ectopic H3 T3 phosphorylation, triggering precocious SCC release without impairing earlier HTP-1 roles in homolog pairing and recombination. CDK-1 exerts temporal regulation of Aurora B recruitment, coupling REC-8 phosphorylation to oocyte maturation. Our findings elucidate a complex regulatory network that uses chromosome axis components, H3 T3 phosphorylation, and cell cycle regulators to ensure accurate chromosome segregation during oogenesis.

Date: 2018
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DOI: 10.1038/s41467-018-03229-5

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