Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

Cui-Ping Yang, Xiaoyan Li, Yong Wu, Qiushuo Shen, Yong Zeng, Qiuxia Xiong, Mengping Wei, Chunhui Chen, Jiewei Liu, Yongxia Huo, Kaiqin Li, Gui Xue, Yong-Gang Yao, Chen Zhang, Ming Li, Yongbin Chen () and Xiong-Jian Luo ()
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Cui-Ping Yang: Chinese Academy of Sciences
Xiaoyan Li: Chinese Academy of Sciences
Yong Wu: Chinese Academy of Sciences
Qiushuo Shen: Chinese Academy of Sciences
Yong Zeng: The First Affiliated Hospital of Kunming Medical College
Qiuxia Xiong: The First Affiliated Hospital of Kunming Medical College
Mengping Wei: School of Life Sciences, Peking University
Chunhui Chen: Beijing Normal University
Jiewei Liu: Chinese Academy of Sciences
Yongxia Huo: Chinese Academy of Sciences
Kaiqin Li: Chinese Academy of Sciences
Gui Xue: Beijing Normal University
Yong-Gang Yao: Chinese Academy of Sciences
Chen Zhang: School of Life Sciences, Peking University
Ming Li: Chinese Academy of Sciences
Yongbin Chen: Chinese Academy of Sciences
Xiong-Jian Luo: Chinese Academy of Sciences

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract Recent genome-wide association studies (GWAS) have identified multiple risk loci that show strong associations with schizophrenia. However, pinpointing the potential causal genes at the reported loci remains a major challenge. Here we identify candidate causal genes for schizophrenia using an integrative genomic approach. Sherlock integrative analysis shows that ALMS1, GLT8D1, and CSNK2B are schizophrenia risk genes, which are validated using independent brain expression quantitative trait loci (eQTL) data and integrative analysis method (SMR). Consistently, gene expression analysis in schizophrenia cases and controls further supports the potential role of these three genes in the pathogenesis of schizophrenia. Finally, we show that GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of neurons. These convergent lines of evidence suggest that the ALMS1, CSNK2B, and GLT8D1 genes may be involved in pathophysiology of schizophrenia.

Date: 2018
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DOI: 10.1038/s41467-018-03247-3

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