Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Marlena S. Fejzo (), Olga V. Sazonova, J. Fah Sathirapongsasuti, Ingileif B. Hallgrímsdóttir, Vladimir Vacic, Kimber W. MacGibbon, Frederic P. Schoenberg, Nicholas Mancuso, Dennis J. Slamon and Patrick M. Mullin
Additional contact information
Marlena S. Fejzo: University of California at Los Angeles
Olga V. Sazonova: 23andMe, Inc.
J. Fah Sathirapongsasuti: 23andMe, Inc.
Ingileif B. Hallgrímsdóttir: 23andMe, Inc.
Vladimir Vacic: 23andMe, Inc.
Kimber W. MacGibbon: Hyperemesis Education and Research Foundation
Frederic P. Schoenberg: University of California, Los Angeles
Nicholas Mancuso: University of California at Los Angeles
Dennis J. Slamon: University of California at Los Angeles
Patrick M. Mullin: University of Southern California

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-018-03258-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03258-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-03258-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().