A systematic approach to the development of a safe live attenuated Zika vaccine

Swee Sen Kwek, Satoru Watanabe, Kuan Rong Chan, Eugenia Z. Ong, Hwee Cheng Tan, Wy Ching Ng, Mien T. X. Nguyen, Esther S. Gan, Summer L. Zhang, Kitti W. K. Chan, Jun Hao Tan, October M. Sessions, Menchie Manuel, Julien Pompon, Camillus Chua, Sharifah Hazirah, Karl Tryggvason, Subhash G. Vasudevan and Eng Eong Ooi ()
Additional contact information
Swee Sen Kwek: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Satoru Watanabe: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Kuan Rong Chan: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Eugenia Z. Ong: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Hwee Cheng Tan: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Wy Ching Ng: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Mien T. X. Nguyen: Programme in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
Esther S. Gan: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Summer L. Zhang: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Kitti W. K. Chan: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Jun Hao Tan: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
October M. Sessions: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Menchie Manuel: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Julien Pompon: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Camillus Chua: SingHealth Translational Immunology and Inflammation Centre, SingHealth
Sharifah Hazirah: SingHealth Translational Immunology and Inflammation Centre, SingHealth
Karl Tryggvason: Programme in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
Subhash G. Vasudevan: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School
Eng Eong Ooi: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties similar to the yellow fever 17D (YF17D) live-attenuated vaccine (LAV) would be advantageous, as a single dose of YF17D produces lifelong immunity. However, a replicative ZIKV vaccine must also be safe from causing persistent organ infections. Here we report an approach to ZIKV LAV development. We identify a ZIKV variant that produces small plaques due to interferon (IFN)-restricted viral propagation and displays attenuated infection of endothelial cells. We show that these properties collectively reduce the risk of organ infections and vertical transmission in a mouse model but remain sufficiently immunogenic to prevent wild-type ZIKV infection. Our findings suggest a strategy for the development of a safe but efficacious ZIKV LAV.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-03337-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03337-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-03337-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().