A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

Hao Wan, Jingying Yue, Shoujun Zhu, Takaaki Uno, Xiaodong Zhang, Qinglai Yang, Kuai Yu, Guosong Hong, Junying Wang, Lulin Li, Zhuoran Ma, Hongpeng Gao, Yeteng Zhong, Jessica Su, Alexander L. Antaris, Yan Xia, Jian Luo, Yongye Liang () and Hongjie Dai ()
Additional contact information
Hao Wan: South University of Science and Technology of China
Jingying Yue: Stanford University
Shoujun Zhu: Stanford University
Takaaki Uno: Stanford University
Xiaodong Zhang: Tianjin University
Qinglai Yang: South University of Science and Technology of China
Kuai Yu: Stanford University
Guosong Hong: Stanford University
Junying Wang: Tianjin University
Lulin Li: VA Palo Alto Health Care System
Zhuoran Ma: Stanford University
Hongpeng Gao: Stanford University
Yeteng Zhong: Stanford University
Jessica Su: Stanford University
Alexander L. Antaris: Stanford University
Yan Xia: Stanford University
Jian Luo: VA Palo Alto Health Care System
Yongye Liang: South University of Science and Technology of China
Hongjie Dai: Stanford University

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Fluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000–1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II >1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels. Excitingly, p-FE enables one-photon based, three-dimensional (3D) confocal imaging of vasculatures in fixed mouse brain tissue with a layer-by-layer imaging depth up to ~1.3 mm and sub-10 µm high spatial resolution. We also perform in vivo two-color fluorescence imaging in the NIR-II window by utilizing p-FE as a vasculature imaging agent emitting between 1100 and 1300 nm and single-walled carbon nanotubes (CNTs) emitting above 1500 nm to highlight tumors in mice.

Date: 2018
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DOI: 10.1038/s41467-018-03505-4

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