The choroid plexus is an important circadian clock component

Jihwan Myung (), Christoph Schmal, Sungho Hong, Yoshiaki Tsukizawa, Pia Rose, Yong Zhang, Michael J. Holtzman, Erik De Schutter, Hanspeter Herzel (), Grigory Bordyugov and Toru Takumi ()
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Jihwan Myung: RIKEN Brain Science Institute (BSI)
Christoph Schmal: Charité-Universitätsmedizin and Humboldt Universität
Sungho Hong: Okinawa Institute of Science and Technology
Yoshiaki Tsukizawa: Hiroshima University School of Medicine
Pia Rose: Charité-Universitätsmedizin and Humboldt Universität
Yong Zhang: Washington University School of Medicine
Michael J. Holtzman: Washington University School of Medicine
Erik De Schutter: Okinawa Institute of Science and Technology
Hanspeter Herzel: Charité-Universitätsmedizin and Humboldt Universität
Grigory Bordyugov: Charité-Universitätsmedizin and Humboldt Universität
Toru Takumi: RIKEN Brain Science Institute (BSI)

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Mammalian circadian clocks have a hierarchical organization, governed by the suprachiasmatic nucleus (SCN) in the hypothalamus. The brain itself contains multiple loci that maintain autonomous circadian rhythmicity, but the contribution of the non-SCN clocks to this hierarchy remains unclear. We examine circadian oscillations of clock gene expression in various brain loci and discovered that in mouse, robust, higher amplitude, relatively faster oscillations occur in the choroid plexus (CP) compared to the SCN. Our computational analysis and modeling show that the CP achieves these properties by synchronization of “twist” circadian oscillators via gap-junctional connections. Using an in vitro tissue coculture model and in vivo targeted deletion of the Bmal1 gene to silence the CP circadian clock, we demonstrate that the CP clock adjusts the SCN clock likely via circulation of cerebrospinal fluid, thus finely tuning behavioral circadian rhythms.

Date: 2018
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DOI: 10.1038/s41467-018-03507-2

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