Biomimetic temporal self-assembly via fuel-driven controlled supramolecular polymerization

Ananya Mishra, Divya B. Korlepara, Mohit Kumar, Ankit Jain, Narendra Jonnalagadda, Karteek K. Bejagam, Sundaram Balasubramanian () and Subi J. George ()
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Ananya Mishra: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Divya B. Korlepara: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Mohit Kumar: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Ankit Jain: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Narendra Jonnalagadda: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Karteek K. Bejagam: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Sundaram Balasubramanian: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)
Subi J. George: Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR)

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Temporal control of supramolecular assemblies to modulate the structural and transient characteristics of synthetic nanostructures is an active field of research within supramolecular chemistry. Molecular designs to attain temporal control have often taken inspiration from biological assemblies. One such assembly in Nature which has been studied extensively, for its well-defined structure and programmable self-assembly, is the ATP-driven seeded self-assembly of actin. Here we show, in a synthetic manifestation of actin self-assembly, an ATP-selective and ATP-fuelled, controlled supramolecular polymerization of a phosphate receptor functionalised monomer. It undergoes fuel-driven nucleation and seeded growth that provide length control and narrow dispersity of the resultant assemblies. Furthermore, coupling via ATP-hydrolysing enzymes yielded its transient characteristics. These results will usher investigations into synthetic analogues of important biological self-assembly motifs and will prove to be a significant advancement toward biomimetic temporally programmed materials.

Date: 2018
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DOI: 10.1038/s41467-018-03542-z

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