nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

Ji-Hye Ahn, Hyun-Sung Lee, Ju-Seog Lee, Yeon-Su Lee, Jong-Lyul Park, Seon-Young Kim, Jung-Ah Hwang, Nawapol Kunkeaw, Sung Yun Jung, Tae Jin Kim, Kwang-Soo Lee, Sung Ho Jeon, Inhan Lee, Betty H. Johnson, Jung-Hye Choi () and Yong Sun Lee ()
Additional contact information
Ji-Hye Ahn: Kyung Hee University
Hyun-Sung Lee: Baylor College of Medicine
Ju-Seog Lee: University of Texas MD Anderson Cancer Center
Yeon-Su Lee: National Cancer Center
Jong-Lyul Park: KRIBB
Seon-Young Kim: KRIBB
Jung-Ah Hwang: National Cancer Center
Nawapol Kunkeaw: University of Texas Medical Branch
Sung Yun Jung: Baylor College of Medicine
Tae Jin Kim: College of Medicine Dankook University
Kwang-Soo Lee: Hallym University
Sung Ho Jeon: Hallym University
Inhan Lee: miRcore
Betty H. Johnson: University of Texas Medical Branch
Jung-Hye Choi: Kyung Hee University
Yong Sun Lee: University of Texas Medical Branch

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subtype of ovarian cancer (OC) that is of poor prognosis. However, the interplay between the two pathways in the OC subtype has not yet been elucidated. nc886 is a recently identified non-coding RNA implicated in several malignancies. The high expression of nc886 is associated with poor prognosis in 285 OC patients. Herein, we find that in OC nc886 expression is induced by TGF-β and that nc886 binds to Dicer to inhibit miRNA maturation. By preventing the miRNA pathway, nc886 emulates TGF-β in gene expression patterns and potentiates cell adhesion, migration, invasion, and drug resistance. Here we report nc886 to be a molecular link between the TGF-β and miRNA pathways.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-03556-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03556-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-03556-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().