A biochemical network controlling basal myosin oscillation

Xiang Qin, Edouard Hannezo, Thomas Mangeat, Chang Liu, Pralay Majumder, Jiaying Liu, Valerie Choesmel-Cadamuro, Jocelyn A. McDonald, Yiyao Liu (), Bin Yi () and Xiaobo Wang ()
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Xiang Qin: Université de Toulouse, UPS
Edouard Hannezo: University of Cambridge
Thomas Mangeat: Université de Toulouse, UPS
Chang Liu: Université de Toulouse, UPS
Pralay Majumder: Presidency University
Jiaying Liu: Université de Toulouse, UPS
Valerie Choesmel-Cadamuro: Université de Toulouse, UPS
Jocelyn A. McDonald: Kansas State University
Yiyao Liu: University of Electronic Science and Technology of China
Bin Yi: Third Military Medical University
Xiaobo Wang: Université de Toulouse, UPS

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscillation in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension, but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase. Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial actomyosin cortex, and dynamically maintained by a self-activation loop reliant on ROCK kinase activity. In response to the resulting myosin II recruitment, myosin phosphatase is locally enriched and shuts off ROCK and myosin II signals. Coupling Drosophila genetics, live imaging, modeling, and optogenetics, we uncover an intrinsic biochemical oscillator at the core of myosin II regulatory network, shedding light on the spatio-temporal dynamics of force generation.

Date: 2018
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DOI: 10.1038/s41467-018-03574-5

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