A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

Natalie A. Prow, Liang Liu, Eri Nakayama, Tamara H. Cooper, Kexin Yan, Preethi Eldi, Jessamine E. Hazlewood, Bing Tang, Thuy T. Le, Yin Xiang Setoh, Alexander A Khromykh, Jody Hobson-Peters, Kerrilyn R. Diener, Paul M. Howley (), John D. Hayball () and Andreas Suhrbier ()
Additional contact information
Natalie A. Prow: QIMR Berghofer Medical Research Institute
Liang Liu: University of South Australia
Eri Nakayama: QIMR Berghofer Medical Research Institute
Tamara H. Cooper: University of South Australia
Kexin Yan: QIMR Berghofer Medical Research Institute
Preethi Eldi: University of South Australia
Jessamine E. Hazlewood: QIMR Berghofer Medical Research Institute
Bing Tang: QIMR Berghofer Medical Research Institute
Thuy T. Le: QIMR Berghofer Medical Research Institute
Yin Xiang Setoh: University of Queensland
Alexander A Khromykh: Australian Infectious Disease Research Centre
Jody Hobson-Peters: University of Queensland
Kerrilyn R. Diener: University of South Australia
Paul M. Howley: Sementis Ltd.
John D. Hayball: University of South Australia
Andreas Suhrbier: QIMR Berghofer Medical Research Institute

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Zika and chikungunya viruses have caused major epidemics and are transmitted by Aedes aegypti and/or Aedes albopictus mosquitoes. The “Sementis Copenhagen Vector” (SCV) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified CHO cells. Herein we describe a single-vector construct SCV vaccine that encodes the structural polyprotein cassettes of both Zika and chikungunya viruses from different loci. A single vaccination of mice induces neutralizing antibodies to both viruses in wild-type and IFNAR−/− mice and protects against (i) chikungunya virus viremia and arthritis in wild-type mice, (ii) Zika virus viremia and fetal/placental infection in female IFNAR−/− mice, and (iii) Zika virus viremia and testes infection and pathology in male IFNAR−/− mice. To our knowledge this represents the first single-vector construct, multi-pathogen vaccine encoding large polyproteins, and offers both simplified manufacturing and formulation, and reduced “shot burden” for these often co-circulating arboviruses.

Date: 2018
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DOI: 10.1038/s41467-018-03662-6

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