TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling

Baozhu Zhang, Zhao Zhang, Lei Li, Yan-Ru Qin, Haibo Liu, Chen Jiang, Ting-Ting Zeng, Meng-Qing Li, Dan Xie, Yan Li (), Xin-Yuan Guan () and Ying-Hui Zhu ()
Additional contact information
Baozhu Zhang: Collaborative Innovation Center for Cancer Medicine
Zhao Zhang: Hainan Cancer Hospital
Lei Li: Collaborative Innovation Center for Cancer Medicine
Yan-Ru Qin: Zhengzhou University
Haibo Liu: The Third Affiliated Hospital of Guangzhou Medical University
Chen Jiang: The University of Hong Kong
Ting-Ting Zeng: Collaborative Innovation Center for Cancer Medicine
Meng-Qing Li: Collaborative Innovation Center for Cancer Medicine
Dan Xie: Collaborative Innovation Center for Cancer Medicine
Yan Li: Collaborative Innovation Center for Cancer Medicine
Xin-Yuan Guan: Collaborative Innovation Center for Cancer Medicine
Ying-Hui Zhu: Collaborative Innovation Center for Cancer Medicine

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) is crucial for the degradation of IκBα. Our previous transcriptome sequencing analysis revealed that tetraspanin 15 (TSPAN15) was significantly upregulated in clinical oesophageal squamous cell carcinoma (OSCC) tissues. Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis. Elevated TSPAN15 expression is, in part, caused by the reduction of miR-339-5p. Functional studies demonstrate that TSPAN15 promotes metastatic capabilities of OSCC cells. We further show that TSPAN15 specifically interacts with BTRC to promote the ubiquitination and proteasomal degradation of p-IκBα, and thereby triggers NF-κB nuclear translocation and subsequent activation of transcription of several metastasis-related genes, including ICAM1, VCAM1, uPA, MMP9, TNFα, and CCL2. Collectively, our findings indicate that TSPAN15 may serve as a new biomarker and/or provide a novel therapeutic target to OSCC patients.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-03716-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03716-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-03716-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().