Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing

Soon Hee Kim, Yeung Kyu Yeon, Jung Min Lee, Janet Ren Chao, Young Jin Lee, Ye Been Seo, Md. Tipu Sultan, Ok Joo Lee, Ji Seung Lee, Sung-il Yoon, In-Sun Hong, Gilson Khang, Sang Jin Lee, James J. Yoo and Chan Hum Park ()
Additional contact information
Soon Hee Kim: Hallym University
Yeung Kyu Yeon: Hallym University
Jung Min Lee: Hallym University
Janet Ren Chao: George Washington University
Young Jin Lee: Hallym University
Ye Been Seo: Hallym University
Md. Tipu Sultan: Hallym University
Ok Joo Lee: Hallym University
Ji Seung Lee: Hallym University
Sung-il Yoon: Kangwon National University
In-Sun Hong: Gachon University
Gilson Khang: Chonbuk National University
Sang Jin Lee: Medical Center Boulevard
James J. Yoo: Medical Center Boulevard
Chan Hum Park: Hallym University

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements.

Date: 2018
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DOI: 10.1038/s41467-018-03759-y

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