Synaptically silent sensory hair cells in zebrafish are recruited after damage

Qiuxiang Zhang, Suna Li, Hiu-Tung C. Wong, Xinyi J. He, Alisha Beirl, Ronald S. Petralia, Ya-Xian Wang and Katie S. Kindt ()
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Qiuxiang Zhang: NIDCD/National Institutes of Health
Suna Li: NIDCD/National Institutes of Health
Hiu-Tung C. Wong: NIDCD/National Institutes of Health
Xinyi J. He: NIDCD/National Institutes of Health
Alisha Beirl: NIDCD/National Institutes of Health
Ronald S. Petralia: NIDCD/National Institutes of Health
Ya-Xian Wang: NIDCD/National Institutes of Health
Katie S. Kindt: NIDCD/National Institutes of Health

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract Analysis of mechanotransduction among ensembles of sensory hair cells in vivo is challenging in many species. To overcome this challenge, we used optical indicators to investigate mechanotransduction among collections of hair cells in intact zebrafish. Our imaging reveals a previously undiscovered disconnect between hair-cell mechanosensation and synaptic transmission. We show that saturating mechanical stimuli able to open mechanically gated channels are unexpectedly insufficient to evoke vesicle fusion in the majority of hair cells. Although synaptically silent, latent hair cells can be rapidly recruited after damage, demonstrating that they are synaptically competent. Therefore synaptically silent hair cells may be an important reserve that acts to maintain sensory function. Our results demonstrate a previously unidentified level of complexity in sculpting sensory transmission from the periphery.

Date: 2018
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DOI: 10.1038/s41467-018-03806-8

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