Stimulus dependent diversity and stereotypy in the output of an olfactory functional unit

Ezequiel M. Arneodo, Kristina B. Penikis, Neil Rabinowitz, Angela Licata, Annika Cichy, Jingji Zhang, Thomas Bozza and Dmitry Rinberg ()
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Ezequiel M. Arneodo: NYU Langone Health
Kristina B. Penikis: NYU Langone Health
Neil Rabinowitz: New York University
Angela Licata: NYU Langone Health
Annika Cichy: Northwestern University
Jingji Zhang: Northwestern University
Thomas Bozza: Northwestern University
Dmitry Rinberg: NYU Langone Health

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Olfactory inputs are organized in an array of functional units (glomeruli), each relaying information from sensory neurons expressing a given odorant receptor to a small population of output neurons, mitral/tufted (MT) cells. MT cells respond heterogeneously to odorants, and how the responses encode stimulus features is unknown. We recorded in awake mice responses from “sister” MT cells that receive input from a functionally characterized, genetically identified glomerulus, corresponding to a specific receptor (M72). Despite receiving similar inputs, sister MT cells exhibit temporally diverse, concentration-dependent, excitatory and inhibitory responses to most M72 ligands. In contrast, the strongest known ligand for M72 elicits temporally stereotyped, early excitatory responses in sister MT cells, consistent across a range of concentrations. Our data suggest that information about ligand affinity is encoded in the collective stereotypy or diversity of activity among sister MT cells within a glomerular functional unit in a concentration-tolerant manner.

Date: 2018
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DOI: 10.1038/s41467-018-03837-1

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