Matriptase-2 deficiency protects from obesity by modulating iron homeostasis

Alicia R. Folgueras (), Sandra Freitas-Rodríguez, Andrew J. Ramsay, Cecilia Garabaya, Francisco Rodríguez, Gloria Velasco and Carlos López-Otín ()
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Alicia R. Folgueras: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo
Sandra Freitas-Rodríguez: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo
Andrew J. Ramsay: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo
Cecilia Garabaya: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo
Francisco Rodríguez: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo
Gloria Velasco: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo
Carlos López-Otín: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Alterations in iron status have frequently been associated with obesity and other metabolic disorders. The hormone hepcidin stands out as a key regulator in the maintenance of iron homeostasis by controlling the main iron exporter, ferroportin. Here we demonstrate that the deficiency in the hepcidin repressor matriptase-2 (Tmprss6) protects from high-fat diet-induced obesity. Tmprss6 −/− mice show a significant decrease in body fat, improved glucose tolerance and insulin sensitivity, and are protected against hepatic steatosis. Moreover, these mice exhibit a significant increase in fat lipolysis, consistent with their dramatic reduction in adiposity. Rescue experiments that block hepcidin up-regulation and restore iron levels in Tmprss6−/− mice via anti-hemojuvelin (HJV) therapy, revert the obesity-resistant phenotype of Tmprss6−/− mice. Overall, this study describes a role for matritpase-2 and hepcidin in obesity and highlights the relevance of iron regulation in the control of adipose tissue function.

Date: 2018
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DOI: 10.1038/s41467-018-03853-1

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