Gold nanocrystal-mediated sliding of doublet DNA origami filaments

Maximilian J. Urban, Steffen Both, Chao Zhou (), Anton Kuzyk, Klas Lindfors, Thomas Weiss and Na Liu ()
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Maximilian J. Urban: Max Planck Institute for Intelligent Systems
Steffen Both: University of Stuttgart
Chao Zhou: Max Planck Institute for Intelligent Systems
Anton Kuzyk: Max Planck Institute for Intelligent Systems
Klas Lindfors: University of Cologne
Thomas Weiss: University of Stuttgart
Na Liu: Max Planck Institute for Intelligent Systems

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Sliding is one of the fundamental mechanical movements in machinery. In macroscopic systems, double-rack pinion machines employ gears to slide two linear tracks along opposite directions. In microscopic systems, kinesin-5 proteins crosslink and slide apart antiparallel microtubules, promoting spindle bipolarity and elongation during mitosis. Here we demonstrate an artificial nanoscopic analog, in which gold nanocrystals can mediate coordinated sliding of two antiparallel DNA origami filaments powered by DNA fuels. Stepwise and reversible sliding along opposite directions is in situ monitored and confirmed using fluorescence spectroscopy. A theoretical model including different energy transfer mechanisms is developed to understand the observed fluorescence dynamics. We further show that such sliding can also take place in the presence of multiple DNA sidelocks that are introduced to inhibit the relative movements. Our work enriches the toolbox of DNA-based nanomachinery, taking one step further toward the vision of molecular nanofactories.

Date: 2018
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DOI: 10.1038/s41467-018-03882-w

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