A proteomics landscape of circadian clock in mouse liver

Yunzhi Wang, Lei Song, Mingwei Liu, Rui Ge, Quan Zhou, Wanlin Liu, Ruiyang Li, Jingbo Qie, Bei Zhen, Yi Wang, Fuchu He (), Jun Qin () and Chen Ding ()
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Yunzhi Wang: Fudan University
Lei Song: Tsinghua University
Mingwei Liu: National Center for Protein Sciences
Rui Ge: Fudan University
Quan Zhou: National Center for Protein Sciences
Wanlin Liu: National Center for Protein Sciences
Ruiyang Li: Fudan University
Jingbo Qie: Fudan University
Bei Zhen: National Center for Protein Sciences
Yi Wang: National Center for Protein Sciences
Fuchu He: Fudan University
Jun Qin: Fudan University
Chen Ding: Fudan University

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a transcription factor (TF) DNA-binding activity-centered multi-dimensional proteomics landscape of the mouse liver, which includes DNA-binding profiles of different TFs, phosphorylation, and ubiquitylation patterns, the nuclear sub-proteome, the whole proteome as well as the transcriptome, to portray the hierarchical circadian clock network of this tissue. The TF DNA-binding activity indicates diurnal oscillation in four major pathways, namely the immune response, glucose metabolism, fatty acid metabolism, and the cell cycle. We also isolate the mouse liver Kupffer cells and measure their proteomes during the circadian cycle to reveal a cell-type resolved circadian clock. These comprehensive data sets provide a rich data resource for the understanding of mouse hepatic physiology around the circadian clock.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03898-2

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DOI: 10.1038/s41467-018-03898-2

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