In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang, Xiyun Yan () and Lizeng Gao ()
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Kelong Fan: Chinese Academy of Sciences
Juqun Xi: Yangzhou University
Lei Fan: Yangzhou University
Peixia Wang: Chinese Academy of Sciences
Chunhua Zhu: Yangzhou University
Yan Tang: Yangzhou University
Xiangdong Xu: Yangzhou University
Minmin Liang: Chinese Academy of Sciences
Bing Jiang: Chinese Academy of Sciences
Xiyun Yan: Chinese Academy of Sciences
Lizeng Gao: Yangzhou University

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as artificial enzymes in biomedicine. However, how to control their in vivo performance in a target cell is still challenging. Here we report a strategy to coordinate nanozymes to target tumor cells and selectively perform their activity to destruct tumors. We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive oxygen species regulation. We then introduce ferritin to guide nitrogen-doped porous carbon nanospheres into lysosomes and boost reactive oxygen species generation in a tumor-specific manner, resulting in significant tumor regression in human tumor xenograft mice models. Together, our study provides evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanozymes to target tumor cells for in vivo tumor catalytic therapy.

Date: 2018
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DOI: 10.1038/s41467-018-03903-8

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