HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development

Liang Zhou, Yinghui Wang, Meijuan Zhou, Ying Zhang, Pengfei Wang, Xiaoxing Li, Jing Yang, Hongmei Wang and Zhenhua Ding ()
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Liang Zhou: Southern Medical University
Yinghui Wang: Southern Medical University
Meijuan Zhou: Southern Medical University
Ying Zhang: Southern Medical University
Pengfei Wang: Southern Medical University
Xiaoxing Li: Sun Yat-sen University Cancer Center
Jing Yang: Sun Yat-sen University Cancer Center
Hongmei Wang: Sun Yat-sen University Cancer Center
Zhenhua Ding: Southern Medical University

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract Glycolytic reprogramming is a typical feature of many cancers; however, key regulators of glucose metabolism reengineering are poorly understood, especially in cutaneous squamous cell carcinoma (cSCC). Here, Homeobox A9 (HOXA9), a direct target of onco-miR-365, is identified to be significantly downregulated in cSCC tumors and cell lines. HOXA9 acts as a tumor suppressor and inhibits glycolysis in cSCC in vitro and in vivo by negatively regulating HIF-1α and its downstream glycolytic regulators, HK2, GLUT1 and PDK1. Mechanistic studies show that HOXA9-CRIP2 interaction at glycolytic gene promoters impeds HIF-1α binding, repressing gene expression in trans. Our results reveal a miR-365-HOXA9-HIF-1α regulatory axis that contributes to the enhanced glycolysis in cSCC development and may represent an intervention target for cSCC therapy.

Date: 2018
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DOI: 10.1038/s41467-018-03914-5

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