A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

Mingtang Xie, Hongyu Chen, Ling Huang, Ryan C. O’Neil, Maxim N. Shokhirev and Joseph R. Ecker ()
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Mingtang Xie: The Salk Institute for Biological Studies
Hongyu Chen: Dartmouth College
Ling Huang: The Salk Institute for Biological Studies
Ryan C. O’Neil: The Salk Institute for Biological Studies
Maxim N. Shokhirev: The Salk Institute for Biological Studies
Joseph R. Ecker: The Salk Institute for Biological Studies

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Cytokinin fulfills its diverse roles in planta through a series of transcriptional responses. We identify the in vivo DNA binding site profiles for three genetically redundant type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs): ARR1, ARR10, and ARR12. The expression and genome-wide DNA binding locations of the three B-ARRs extensively overlap. Constructing a primary cytokinin response transcriptional network reveals a recurring theme of widespread cross-regulation between the components of the cytokinin pathway and other plant hormone pathways. The B-ARRs are found to have similar DNA binding motifs, though sequences flanking the core motif were degenerate. Cytokinin treatments amalgamate the three different B-ARRs motifs to identical DNA binding signatures (AGATHY, H(a/t/c), Y(t/c)) which suggests cytokinin may regulate binding activity of B-ARR family members. Furthermore, we find that WUSCHEL, a key gene required for apical meristem maintenance, is a cytokinin-dependent B-ARR target gene, demonstrating the importance of the cytokinin transcription factor network in shoot development.

Date: 2018
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DOI: 10.1038/s41467-018-03921-6

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