Single synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo

Jean-Sébastien Jouhanneau, Jens Kremkow and James F. A. Poulet ()
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Jean-Sébastien Jouhanneau: Max Delbrück Center for Molecular Medicine (MDC)
Jens Kremkow: Max Delbrück Center for Molecular Medicine (MDC)
James F. A. Poulet: Max Delbrück Center for Molecular Medicine (MDC)

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract A defining feature of cortical layer 2/3 excitatory neurons is their sparse activity, often firing in singlets of action potentials. Local inhibitory neurons are thought to play a major role in regulating sparseness, but which cell types are recruited by single excitatory synaptic inputs is unknown. Using multiple, targeted, in vivo whole-cell recordings, we show that single uEPSPs have little effect on the firing rates of excitatory neurons and somatostatin-expressing GABA-ergic inhibitory neurons but evoke precisely timed action potentials in parvalbumin-expressing inhibitory neurons. Despite a uEPSP decay time of 7.8 ms, the evoked action potentials were almost completely restricted to the uEPSP rising phase (~0.5 ms). Evoked parvalbumin-expressing neuron action potentials go on to inhibit the local excitatory network, thus providing a pathway for single spike evoked disynaptic inhibition which may enforce sparse and precisely timed cortical signaling.

Date: 2018
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DOI: 10.1038/s41467-018-03995-2

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