The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

Martin S. Davey (), Carrie R. Willcox, Stuart Hunter, Sofya A. Kasatskaya, Ester B. M. Remmerswaal, Mahboob Salim, Fiyaz Mohammed, Frederike J. Bemelman, Dmitriy M. Chudakov, Ye H. Oo and Benjamin E. Willcox ()
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Martin S. Davey: University of Birmingham
Carrie R. Willcox: University of Birmingham
Stuart Hunter: University of Birmingham
Sofya A. Kasatskaya: Russian Academy of Science
Ester B. M. Remmerswaal: Academic Medical Center
Mahboob Salim: University of Birmingham
Fiyaz Mohammed: University of Birmingham
Frederike J. Bemelman: Academic Medical Center
Dmitriy M. Chudakov: Russian Academy of Science
Ye H. Oo: University of Birmingham
Benjamin E. Willcox: University of Birmingham

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the Vδ2+ compartment comprises both innate-like and adaptive subsets. Vγ9+ Vδ2+ T cells display semi-invariant TCR repertoires, featuring public Vγ9 TCR sequences equivalent in cord and adult blood. By contrast, we also identify a separate, Vγ9− Vδ2+ T-cell subset that typically has a CD27hiCCR7+CD28+IL-7Rα+ naive-like phenotype and a diverse TCR repertoire, however in response to viral infection, undergoes clonal expansion and differentiation to a CD27loCD45RA+CX3CR1+granzymeA/B+ effector phenotype. Consistent with a function in solid tissue immunosurveillance, we detect human intrahepatic Vγ9− Vδ2+ T cells featuring dominant clonal expansions and an effector phenotype. These findings redefine human γδ T-cell subsets by delineating the Vδ2+ T-cell compartment into innate-like (Vγ9+) and adaptive (Vγ9−) subsets, which have distinct functions in microbial immunosurveillance.

Date: 2018
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DOI: 10.1038/s41467-018-04076-0

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