Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

Alessia Visconti, David L. Duffy, Fan Liu, Gu Zhu, Wenting Wu, Yan Chen, Pirro G. Hysi, Changqing Zeng, Marianna Sanna, Mark M. Iles, Peter A. Kanetsky, Florence Demenais, Merel A. Hamer, Andre G. Uitterlinden, M. Arfan Ikram, Tamar Nijsten, Nicholas G. Martin, Manfred Kayser, Tim D. Spector, Jiali Han, Veronique Bataille and Mario Falchi ()
Additional contact information
Alessia Visconti: King’s College London
David L. Duffy: QIMR Berghofer Medical Research Institute
Fan Liu: Chinese Academy of Sciences
Gu Zhu: QIMR Berghofer Medical Research Institute
Wenting Wu: Indiana University
Yan Chen: Chinese Academy of Sciences
Pirro G. Hysi: King’s College London
Changqing Zeng: Chinese Academy of Sciences
Marianna Sanna: King’s College London
Mark M. Iles: University of Leeds
Peter A. Kanetsky: H. Lee Moffitt Cancer Center and Research Institute
Florence Demenais: Genetic Variation and Human Diseases Unit
Merel A. Hamer: Erasmus MC University Medical Center Rotterdam
Andre G. Uitterlinden: Erasmus MC University Medical Center Rotterdam
M. Arfan Ikram: Erasmus MC University Medical Center Rotterdam
Tamar Nijsten: Erasmus MC University Medical Center Rotterdam
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Manfred Kayser: Erasmus MC University Medical Center Rotterdam
Tim D. Spector: King’s College London
Jiali Han: Indiana University
Veronique Bataille: King’s College London
Mario Falchi: King’s College London

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.

Date: 2018
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DOI: 10.1038/s41467-018-04086-y

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