A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

Thomas W Winkler (), Felix Günther, Simon Höllerer, Martina Zimmermann, Ruth JF Loos, Zoltán Kutalik and Iris M Heid ()
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Thomas W Winkler: University of Regensburg
Felix Günther: University of Regensburg
Simon Höllerer: University of Regensburg
Martina Zimmermann: University of Regensburg
Ruth JF Loos: Icahn School of Medicine at Mount Sinai
Zoltán Kutalik: Centre Hospitalier Universitaire Vaudois (CHUV)
Iris M Heid: University of Regensburg

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in ~322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (BMI), waist-to-hip ratio (WHR), or WHR adjusted for BMI (WHRadjBMI) at P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04124-9

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DOI: 10.1038/s41467-018-04124-9

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