Catalytic condensation for the formation of polycyclic heteroaromatic compounds

Daniel Forberg, Tobias Schwob and Rhett Kempe ()
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Daniel Forberg: Universität Bayreuth
Tobias Schwob: Universität Bayreuth
Rhett Kempe: Universität Bayreuth

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract The conservation of our global element resources is a challenge of the utmost urgency. Since aliphatic and aromatic alcohols are accessible from abundant indigestible kinds of biomass, first and foremost lignocellulose, the development of novel chemical reactions converting alcohols into important classes of compounds is a particularly attractive carbon conservation and CO2-emission reduction strategy. Herein, we report the catalytic condensation of phenols and aminophenols or aminoalcohols. The overall reaction of this synthesis concept proceeds via three steps: hydrogenation, dehydrogenative condensation and dehydrogenation. Reusable catalysts recently developed in our laboratory mediate these reactions highly efficient. The scope of the concept is exemplarily demonstrated by the synthesis of carbazoles, quinolines and acridines, the structural motifs of which figure prominently in many important natural products, drugs and materials.

Date: 2018
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DOI: 10.1038/s41467-018-04143-6

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