Magnetic nanochain integrated microfluidic biochips

Qirong Xiong, Chun Yee Lim, Jinghua Ren, Jiajing Zhou, Kanyi Pu, Mary B. Chan-Park, Hui Mao, Yee Cheong Lam () and Hongwei Duan ()
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Qirong Xiong: Nanyang Technological University
Chun Yee Lim: Nanyang Technological University
Jinghua Ren: Huazhong University of Science & Technology
Jiajing Zhou: Nanyang Technological University
Kanyi Pu: Nanyang Technological University
Mary B. Chan-Park: Nanyang Technological University
Hui Mao: Emory University
Yee Cheong Lam: Nanyang Technological University
Hongwei Duan: Nanyang Technological University

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Microfluidic biochips hold great potential for liquid analysis in biomedical research and clinical diagnosis. However, the lack of integrated on-chip liquid mixing, bioseparation and signal transduction presents a major challenge in achieving rapid, ultrasensitive bioanalysis in simple microfluidic configurations. Here we report magnetic nanochain integrated microfluidic chip built upon the synergistic functions of the nanochains as nanoscale stir bars for rapid liquid mixing and as capturing agents for specific bioseparation. The use of magnetic nanochains enables a simple planar design of the microchip consisting of flat channels free of common built-in components, such as liquid mixers and surface-anchored sensing elements. The microfluidic assay, using surface-enhanced Raman scattering nanoprobes for signal transduction, allows for streamlined parallel analysis of multiple specimens with greatly improved assay kinetics and delivers ultrasensitive identification and quantification of a panel of cancer protein biomarkers and bacterial species in 1 μl of body fluids within 8 min.

Date: 2018
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DOI: 10.1038/s41467-018-04172-1

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