Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

Sang Cheul Oh, Bo Hwa Sohn, Jae-Ho Cheong, Sang-Bae Kim, Jae Eun Lee, Ki Cheong Park, Sang Ho Lee, Jong-Lyul Park, Yun-Yong Park, Hyun-Sung Lee, Hee-Jin Jang, Eun Sung Park, Sang-Cheol Kim, Jeonghoon Heo, In-Sun Chu, You-Jin Jang, Young-Jae Mok, WonKyung Jung, Baek-Hui Kim, Aeree Kim, Jae Yong Cho, Jae Yun Lim, Yuki Hayashi, Shumei Song, Elena Elimova, Jeannelyn S. Estralla, Jeffrey H. Lee, Manoop S. Bhutani, Yiling Lu, Wenbin Liu, Jeeyun Lee, Won Ki Kang, Sung Kim, Sung Hoon Noh, Gordon B. Mills, Seon-Young Kim, Jaffer A. Ajani and Ju-Seog Lee ()
Additional contact information
Sang Cheul Oh: The University of Texas MD Anderson Cancer Center
Bo Hwa Sohn: The University of Texas MD Anderson Cancer Center
Jae-Ho Cheong: Yonsei University College of Medicine
Sang-Bae Kim: The University of Texas MD Anderson Cancer Center
Jae Eun Lee: Yonsei University College of Medicine
Ki Cheong Park: Yonsei University College of Medicine
Sang Ho Lee: College of Medicine
Jong-Lyul Park: Korea Research Institute of Bioscience and Biotechnology
Yun-Yong Park: University of Ulsan College of Medicine
Hyun-Sung Lee: The University of Texas MD Anderson Cancer Center
Hee-Jin Jang: The University of Texas MD Anderson Cancer Center
Eun Sung Park: Inha University
Sang-Cheol Kim: National Institute of Health
Jeonghoon Heo: College of Medicine
In-Sun Chu: Korea Research Institute of Bioscience and Biotechnology
You-Jin Jang: Korea University
Young-Jae Mok: Korea University
WonKyung Jung: Korea University
Baek-Hui Kim: Korea University
Aeree Kim: Korea University
Jae Yong Cho: Yonsei University College of Medicine
Jae Yun Lim: Yonsei University College of Medicine
Yuki Hayashi: The University of Texas MD Anderson Cancer Center
Shumei Song: The University of Texas MD Anderson Cancer Center
Elena Elimova: The University of Texas MD Anderson Cancer Center
Jeannelyn S. Estralla: The University of Texas MD Anderson Cancer Center
Jeffrey H. Lee: The University of Texas MD Anderson Cancer Center
Manoop S. Bhutani: The University of Texas MD Anderson Cancer Center
Yiling Lu: The University of Texas MD Anderson Cancer Center
Wenbin Liu: The University of Texas MD Anderson Cancer Center
Jeeyun Lee: Division of Hematology-Oncology
Won Ki Kang: Division of Hematology-Oncology
Sung Kim: Samsung Medical Center
Sung Hoon Noh: Yonsei University College of Medicine
Gordon B. Mills: The University of Texas MD Anderson Cancer Center
Seon-Young Kim: Korea Research Institute of Bioscience and Biotechnology
Jaffer A. Ajani: The University of Texas MD Anderson Cancer Center
Ju-Seog Lee: The University of Texas MD Anderson Cancer Center

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy. Integrative analysis shows that signaling pathways driving epithelial-to-mesenchymal transition and insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) pathway are highly activated in MP subtype tumors. Importantly, MP subtype cancer cells are more sensitive to inhibition of IGF1/IGF1R pathway than EP subtype. Detailed characterization of these two subtypes could identify novel therapeutic targets and useful biomarkers for prognosis and therapy response.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-018-04179-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04179-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-04179-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().