Supramolecular Kandinsky circles with high antibacterial activity

Heng Wang, Xiaomin Qian, Kun Wang, Ma Su, Wei-Wei Haoyang, Xin Jiang, Robert Brzozowski, Ming Wang, Xiang Gao, Yiming Li, Bingqian Xu, Prahathees Eswara, Xin-Qi Hao, Weitao Gong (), Jun-Li Hou (), Jianfeng Cai () and Xiaopeng Li ()
Additional contact information
Heng Wang: University of South Florida
Xiaomin Qian: University of South Florida
Kun Wang: University of Georgia
Ma Su: University of South Florida
Wei-Wei Haoyang: Fudan University
Xin Jiang: Jilin University
Robert Brzozowski: University of South Florida
Ming Wang: Jilin University
Xiang Gao: Zhengzhou University
Yiming Li: University of South Florida
Bingqian Xu: University of Georgia
Prahathees Eswara: University of South Florida
Xin-Qi Hao: Zhengzhou University
Weitao Gong: Dalian University of Technology
Jun-Li Hou: Fudan University
Jianfeng Cai: University of South Florida
Xiaopeng Li: University of South Florida

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2−G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.

Date: 2018
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DOI: 10.1038/s41467-018-04247-z

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