Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells

Cristian Vidal, María Tomás-Gamasa, Paolo Destito, Fernando López and José L. Mascareñas ()
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Cristian Vidal: Universidade de Santiago de Compostela
María Tomás-Gamasa: Universidade de Santiago de Compostela
Paolo Destito: Universidade de Santiago de Compostela
Fernando López: Universidade de Santiago de Compostela
José L. Mascareñas: Universidade de Santiago de Compostela

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract The viability of building artificial metabolic pathways within a cell will depend on our ability to design biocompatible and orthogonal catalysts capable of achieving non-natural transformations. In this context, transition metal complexes offer unique possibilities to develop catalytic reactions that do not occur in nature. However, translating the potential of metal catalysts to living cells poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Here we report a gold-mediated C–C bond formation that occurs in complex aqueous habitats, and demonstrate that the reaction can be translated to living mammalian cells. Key to the success of the process is the use of designed, water-activatable gold chloride complexes. Moreover, we demonstrate the viability of achieving the gold-promoted process in parallel with a ruthenium-mediated reaction, inside living cells, and in a bioorthogonal and mutually orthogonal manner.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04314-5

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DOI: 10.1038/s41467-018-04314-5

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