The rice blast resistance gene Ptr encodes an atypical protein required for broad-spectrum disease resistance

Haijun Zhao, Xueyan Wang, Yulin Jia (), Bastian Minkenberg, Matthew Wheatley, Jiangbo Fan, Melissa H. Jia, Adam Famoso, Jeremy D. Edwards, Yeshi Wamishe, Barbara Valent, Guo-Liang Wang and Yinong Yang
Additional contact information
Haijun Zhao: USDA ARS Dale Bumpers National Rice Research Center
Xueyan Wang: USDA ARS Dale Bumpers National Rice Research Center
Yulin Jia: USDA ARS Dale Bumpers National Rice Research Center
Bastian Minkenberg: The Pennsylvania State University, University Park
Matthew Wheatley: The Pennsylvania State University, University Park
Jiangbo Fan: The Ohio State University
Melissa H. Jia: USDA ARS Dale Bumpers National Rice Research Center
Adam Famoso: Louisiana State University Agriculture Center
Jeremy D. Edwards: USDA ARS Dale Bumpers National Rice Research Center
Yeshi Wamishe: University of Arkansas Rice Research and Extension Center
Barbara Valent: Kansas State University
Guo-Liang Wang: The Ohio State University
Yinong Yang: The Pennsylvania State University, University Park

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Plant resistance genes typically encode proteins with nucleotide binding site-leucine rich repeat (NLR) domains. Here we show that Ptr is an atypical resistance gene encoding a protein with four Armadillo repeats. Ptr is required for broad-spectrum blast resistance mediated by the NLR R gene Pi-ta and by the associated R gene Pi-ta2. Ptr is expressed constitutively and encodes two isoforms that are mainly localized in the cytoplasm. A two base pair deletion within the Ptr coding region in the fast neutron-generated mutant line M2354 creates a truncated protein, resulting in susceptibility to M. oryzae. Targeted mutation of Ptr in a resistant cultivar using CRISPR/Cas9 leads to blast susceptibility, further confirming its resistance function. The cloning of Ptr may aid in the development of broad spectrum blast resistant rice.

Date: 2018
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DOI: 10.1038/s41467-018-04369-4

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