Parasitic insect-derived miRNAs modulate host development

Zhi-zhi Wang, Xi-qian Ye, Min Shi, Fei Li, Ze-hua Wang, Yue-nan Zhou, Qi-juan Gu, Xiao-tong Wu, Chuan-lin Yin, Dian-hao Guo, Rong-min Hu, Na-na Hu, Ting Chen, Bo-ying Zheng, Jia-ni Zou, Le-qing Zhan, Shu-jun Wei, Yan-ping Wang, Jian-hua Huang, Xiao-dong Fang, Michael R. Strand and Xue-xin Chen ()
Additional contact information
Zhi-zhi Wang: Zhejiang University
Xi-qian Ye: Zhejiang University
Min Shi: Zhejiang University
Fei Li: Zhejiang University
Ze-hua Wang: Zhejiang University
Yue-nan Zhou: Zhejiang University
Qi-juan Gu: Zhejiang University
Xiao-tong Wu: Zhejiang University
Chuan-lin Yin: Zhejiang University
Dian-hao Guo: Zhejiang University
Rong-min Hu: Zhejiang University
Na-na Hu: Zhejiang University
Ting Chen: Zhejiang University
Bo-ying Zheng: Zhejiang University
Jia-ni Zou: Zhejiang University
Le-qing Zhan: Zhejiang University
Shu-jun Wei: Beijing Academy of Agriculture and Forestry Sciences
Yan-ping Wang: Zhejiang University
Jian-hua Huang: Zhejiang University
Xiao-dong Fang: BGI-Tech, BGI-Shenzhen
Michael R. Strand: University of Georgia
Xue-xin Chen: Zhejiang University

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Parasitic wasps produce several factors including venom, polydnaviruses (PDVs) and specialized wasp cells named teratocytes that benefit the survival of offspring by altering the physiology of hosts. However, the underlying molecular mechanisms for the alterations remain unclear. Here we find that the teratocytes of Cotesia vestalis, an endoparasitoid of the diamondback moth Plutella xylostella, and its associated bracovirus (CvBV) can produce miRNAs and deliver the products into the host via different ways. Certain miRNAs in the parasitized host are mainly produced by teratocytes, while the expression level of miRNAs encoded by CvBV can be 100-fold greater in parasitized hosts than non-parasitized ones. We further show that one teratocyte-produced miRNA (Cve-miR-281-3p) and one CvBV-produced miRNA (Cve-miR-novel22-5p-1) arrest host growth by modulating expression of the host ecdysone receptor (EcR). Altogether, our results show the first evidence of cross-species regulation by miRNAs in animal parasitism and their possible function in the alteration of host physiology during parasitism.

Date: 2018
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DOI: 10.1038/s41467-018-04504-1

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