A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark N. Kvale, Yambazi Banda, Nicholas G. Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair () and Eric Jorgenson ()
Additional contact information
Hélène Choquet: Kaiser Permanente Northern California (KPNC)
Seyyedhassan Paylakhi: University of California San Francisco (UCSF)
Stephen C. Kneeland: Howard Hughes Medical Institute
Khanh K. Thai: Kaiser Permanente Northern California (KPNC)
Thomas J. Hoffmann: UCSF
Jie Yin: Kaiser Permanente Northern California (KPNC)
Mark N. Kvale: UCSF
Yambazi Banda: UCSF
Nicholas G. Tolman: Howard Hughes Medical Institute
Pete A. Williams: Howard Hughes Medical Institute
Catherine Schaefer: Kaiser Permanente Northern California (KPNC)
Ronald B. Melles: KPNC
Neil Risch: Kaiser Permanente Northern California (KPNC)
Simon W. M. John: Howard Hughes Medical Institute
K. Saidas Nair: University of California San Francisco (UCSF)
Eric Jorgenson: Kaiser Permanente Northern California (KPNC)

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, especially in African-Americans who have a higher risk for developing POAG. We conduct a multiethnic genome-wide association study (GWAS) of POAG in the GERA cohort, with replication in the UK Biobank (UKB), and vice versa, GWAS in UKB with replication in GERA. We identify 24 loci (P

Date: 2018
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DOI: 10.1038/s41467-018-04555-4

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