Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

Anne Margarete Merks, Marie Swinarski, Alexander Matthias Meyer, Nicola Victoria Müller, Ismail Özcan, Stefan Donat, Alexa Burger, Stephen Gilbert, Christian Mosimann, Salim Abdelilah-Seyfried and Daniela Panáková ()
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Anne Margarete Merks: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Marie Swinarski: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Alexander Matthias Meyer: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Nicola Victoria Müller: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Ismail Özcan: Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Stefan Donat: University Potsdam
Alexa Burger: University of Zürich
Stephen Gilbert: Max Delbrück Centre for Molecular Medicine in the Helmholtz Association
Christian Mosimann: University of Zürich
Salim Abdelilah-Seyfried: University Potsdam
Daniela Panáková: Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract Development of a multiple-chambered heart from the linear heart tube is inherently linked to cardiac looping. Although many molecular factors regulating the process of cardiac chamber ballooning have been identified, the cellular mechanisms underlying the chamber formation remain unclear. Here, we demonstrate that cardiac chambers remodel by cell neighbour exchange of cardiomyocytes guided by the planar cell polarity (PCP) pathway triggered by two non-canonical Wnt ligands, Wnt5b and Wnt11. We find that PCP signalling coordinates the localisation of actomyosin activity, and thus the efficiency of cell neighbour exchange. On a tissue-scale, PCP signalling planar-polarises tissue tension by restricting the actomyosin contractility to the apical membranes of outflow tract cells. The tissue-scale polarisation of actomyosin contractility is required for cardiac looping that occurs concurrently with chamber ballooning. Taken together, our data reveal that instructive PCP signals couple cardiac chamber expansion with cardiac looping through the organ-scale polarisation of actomyosin-based tissue tension.

Date: 2018
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DOI: 10.1038/s41467-018-04566-1

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