Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa

Vanessa I. Francis, Elaine M. Waters, Sutharsan E. Finton-James, Andrea Gori, Aras Kadioglu, Alan R. Brown and Steven L. Porter ()
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Vanessa I. Francis: University of Exeter
Elaine M. Waters: University of Liverpool
Sutharsan E. Finton-James: University of Exeter
Andrea Gori: University of Exeter
Aras Kadioglu: University of Liverpool
Alan R. Brown: University of Exeter
Steven L. Porter: University of Exeter

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response regulators (RRs). Multikinase networks, where multiple SKs work together, detect and integrate different signals to control important lifestyle decisions such as sporulation and virulence. Here, we study interactions between two SKs from Pseudomonas aeruginosa, GacS and RetS, which control the switch between acute and chronic virulence. We demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation. These mechanisms play important roles in vivo and during infection, and exemplify an unprecedented degree of signal processing by SKs that may be exploited in other multikinase networks.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04640-8

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DOI: 10.1038/s41467-018-04640-8

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