Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit

Nan-Fu Liou, Shih-Han Lin, Ying-Jun Chen, Kuo-Ting Tsai, Chi-Jen Yang, Tzi-Yang Lin, Ting-Han Wu, Hsin-Ju Lin, Yuh-Tarng Chen, Daryl M. Gohl, Marion Silies and Ya-Hui Chou ()
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Nan-Fu Liou: Academia Sinica
Shih-Han Lin: Academia Sinica
Ying-Jun Chen: Academia Sinica
Kuo-Ting Tsai: Academia Sinica
Chi-Jen Yang: Academia Sinica
Tzi-Yang Lin: Academia Sinica
Ting-Han Wu: Academia Sinica
Hsin-Ju Lin: Academia Sinica
Yuh-Tarng Chen: Academia Sinica
Daryl M. Gohl: Stanford University
Marion Silies: Stanford University
Ya-Hui Chou: Academia Sinica

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How and when distinct types of LNs emerge, differentiate, and integrate into the olfactory circuit is unknown. Through systematic developmental analyses, we found that LNs are recruited to the adult olfactory circuit in three groups. Group 1 LNs are residual larval LNs. Group 2 are adult-specific LNs that emerge before cognate sensory and projection neurons establish synaptic specificity, and Group 3 LNs emerge after synaptic specificity is established. Group 1 larval LNs are selectively reintegrated into the adult circuit through pruning and re-extension of processes to distinct regions of the antennal lobe, while others die during metamorphosis. Precise temporal control of this pruning and cell death shapes the global organization of the adult antennal lobe. Our findings provide a road map to understand how LNs develop and contribute to constructing the olfactory circuit.

Date: 2018
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DOI: 10.1038/s41467-018-04675-x

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