Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

David Porciani (), Leah N. Cardwell, Kwaku D. Tawiah, Khalid K. Alam, Margaret J. Lange, Mark A. Daniels and Donald H. Burke ()
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David Porciani: University of Missouri
Leah N. Cardwell: University of Missouri
Kwaku D. Tawiah: University of Missouri
Khalid K. Alam: University of Missouri
Margaret J. Lange: University of Missouri
Mark A. Daniels: University of Missouri
Donald H. Burke: University of Missouri

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Large RNAs and ribonucleoprotein complexes have powerful therapeutic potential, but effective cell-targeted delivery tools are limited. Aptamers that internalize into target cells can deliver siRNAs (

Date: 2018
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DOI: 10.1038/s41467-018-04691-x

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