Computational design of high-performance ligand for enantioselective Markovnikov hydroboration of aliphatic terminal alkenes

Hiroaki Iwamoto, Tsuneo Imamoto and Hajime Ito ()
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Hiroaki Iwamoto: Hokkaido University
Tsuneo Imamoto: Nippon Chemical Industrial Co., Ltd., Kameido
Hajime Ito: Hokkaido University

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract Finding optimal chiral ligands for transition-metal-catalyzed asymmetric reactions using trial-and-error methods is often time-consuming and costly, even if the details of the reaction mechanism are already known. Although modern computational analyses allow the prediction of the stereoselectivity, there are only very few examples for the attempted design of chiral ligands using a computational approach for the improvement of the stereoselectivity. Herein, we report a systematic method for the design of chiral ligands for the enantioselective Markovnikov hydroboration of aliphatic terminal alkenes based on a computational and experimental evaluation sequence. We developed a three-hindered-quadrant P-chirogenic bisphosphine ligand that was designed in accordance with the design guidelines derived from this method, which allowed the Markovnikov hydroboration to proceed with high enantioselectivity (up to 99% ee).

Date: 2018
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DOI: 10.1038/s41467-018-04693-9

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