Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy

Zhen Fan, Yan Chang, Chaochu Cui, Leming Sun, David H. Wang, Zui Pan () and Mingjun Zhang ()
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Zhen Fan: Tongji University
Yan Chang: The University of Texas at Arlington
Chaochu Cui: The University of Texas at Arlington
Leming Sun: Northwestern Polytechnical University
David H. Wang: University of Texas Southwestern Medical Center
Zui Pan: The University of Texas at Arlington
Mingjun Zhang: The Ohio State University

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Various types of nanoparticles have been proposed for targeted drug delivering, imaging, and tracking of therapeutic agents. However, highly biocompatible nanoparticles with structure-induced fluorescence and capability to conjugate with biomarkers and drugs remain lacking. This research proposes and synthesizes fluorescent nanoparticles (f-PNPs) assembled by cyclic peptides to combine imaging and drug delivering for esophageal cancer (EC). To achieve tumor targeting, f-PNPs are first conjugated with RGD moieties to selectively target EC cells via αvβ3 integrin; the nanoparticles are then embedded with epirubicin (EPI). Cell viability assays and analysis of tissue histology reveal that EPI-loaded RGD-f-PNPs (RGD-f-PNPs/EPI) led to significantly reduced cardiotoxicity and improved anti-tumor activity compared to EPI alone. Moreover, the drug delivery to tumor sites and therapeutic responses could be monitored with near-infrared fluorescence using RGD-f-PNPs/EPI. This unique nanoparticle system may lead to potential approaches for bioorganic fluorescence-based delivering, imaging, and drug release tracking.

Date: 2018
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DOI: 10.1038/s41467-018-04763-y

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