Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram

Rongkang Yin, Zheng Xu, Ming Mei, Zhaolong Chen, Kai Wang, Yanlin Liu, Tao Tang, Manish Kr. Priydarshi, Xuejuan Meng, Siyuan Zhao, Bing Deng, Hailin Peng, Zhongfan Liu and Xiaojie Duan ()
Additional contact information
Rongkang Yin: Peking University
Zheng Xu: Peking University
Ming Mei: WuXi App Tec (Suzhou) Co., Ltd
Zhaolong Chen: Peking University
Kai Wang: Peking University People’s Hospital
Yanlin Liu: Peking University People’s Hospital
Tao Tang: Peking University People’s Hospital
Manish Kr. Priydarshi: Peking University
Xuejuan Meng: Peking University
Siyuan Zhao: Peking University
Bing Deng: Peking University
Hailin Peng: Peking University
Zhongfan Liu: Peking University
Xiaojie Duan: Peking University

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Visual electrophysiology measurements are important for ophthalmic diagnostic testing. Electrodes with combined optical transparency and softness are highly desirable, and sometimes indispensable for many ocular electrophysiology measurements. Here we report the fabrication of soft graphene contact lens electrodes (GRACEs) with broad-spectrum optical transparency, and their application in conformal, full-cornea recording of electroretinography (ERG) from cynomolgus monkeys. The GRACEs give higher signal amplitude than conventional ERG electrodes in recordings of various full-field ERG responses. High-quality topographic mapping of multifocal ERG under simultaneous fundus monitoring is realized. A conformal and tight interface between the GRACEs and cornea is revealed. Neither corneal irritation nor abnormal behavior of the animals is observed after ERG measurements with GRACEs. Furthermore, spatially resolved ERG recordings on rabbits with graphene multi-electrode array reveal a stronger signal at the central cornea than the periphery. These results demonstrate the unique capabilities of the graphene-based electrodes for in vivo visual electrophysiology studies.

Date: 2018
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DOI: 10.1038/s41467-018-04781-w

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