Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation

Jonathan Miller, Andrew J. Watrous, Melina Tsitsiklis, Sang Ah Lee, Sameer A. Sheth, Catherine A. Schevon, Elliot H. Smith, Michael R. Sperling, Ashwini Sharan, Ali Akbar Asadi-Pooya, Gregory A. Worrell, Stephen Meisenhelter, Cory S. Inman, Kathryn A. Davis, Bradley Lega, Paul A. Wanda, Sandhitsu R. Das, Joel M. Stein, Richard Gorniak and Joshua Jacobs ()
Additional contact information
Jonathan Miller: Columbia University
Andrew J. Watrous: Columbia University
Melina Tsitsiklis: Columbia University
Sang Ah Lee: Korea Advanced Institute of Science and Technology
Sameer A. Sheth: Baylor College of Medicine
Catherine A. Schevon: Columbia University Medical Center
Elliot H. Smith: Columbia University Medical Center
Michael R. Sperling: Thomas Jefferson University
Ashwini Sharan: Thomas Jefferson University
Ali Akbar Asadi-Pooya: Thomas Jefferson University
Gregory A. Worrell: Mayo Clinic
Stephen Meisenhelter: Geisel School of Medicine at Dartmouth
Cory S. Inman: Emory University School of Medicine
Kathryn A. Davis: Hospital of the University of Pennsylvania
Bradley Lega: University of Texas–Southwestern
Paul A. Wanda: University of Pennsylvania
Sandhitsu R. Das: Hospital of the University of Pennsylvania
Joel M. Stein: Hospital of the University of Pennsylvania
Richard Gorniak: Thomas Jefferson University
Joshua Jacobs: Columbia University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1–3-Hz “low theta” band increases when viewing subsequently remembered object–location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition.

Date: 2018
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DOI: 10.1038/s41467-018-04847-9

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