An intercross population study reveals genes associated with body size and plumage color in ducks

Zhengkui Zhou, Ming Li, Hong Cheng, Wenlei Fan, Zhengrong Yuan, Qiang Gao, Yaxi Xu, Zhanbao Guo, Yunsheng Zhang, Jian Hu, Hehe Liu, Dapeng Liu, Weihuang Chen, Zhuqing Zheng, Yong Jiang, Zhiguo Wen, Yongming Liu, Hua Chen, Ming Xie, Qi Zhang, Wei Huang, Wen Wang, Shuisheng Hou () and Yu Jiang ()
Additional contact information
Zhengkui Zhou: Chinese Academy of Agricultural Sciences
Ming Li: Northwest A&F University
Hong Cheng: Northwest A&F University
Wenlei Fan: Chinese Academy of Agricultural Sciences
Zhengrong Yuan: Beijing Forestry University
Qiang Gao: Chinese Academy of Sciences
Yaxi Xu: Chinese Academy of Agricultural Sciences
Zhanbao Guo: Chinese Academy of Agricultural Sciences
Yunsheng Zhang: Chinese Academy of Agricultural Sciences
Jian Hu: Chinese Academy of Agricultural Sciences
Hehe Liu: Chinese Academy of Agricultural Sciences
Dapeng Liu: Chinese Academy of Agricultural Sciences
Weihuang Chen: Northwest A&F University
Zhuqing Zheng: Northwest A&F University
Yong Jiang: Chinese Academy of Agricultural Sciences
Zhiguo Wen: Chinese Academy of Agricultural Sciences
Yongming Liu: Chinese Academy of Sciences
Hua Chen: Chinese Academy of Sciences
Ming Xie: Chinese Academy of Agricultural Sciences
Qi Zhang: Chinese Academy of Agricultural Sciences
Wei Huang: Chinese Academy of Agricultural Sciences
Wen Wang: Northwestern Polytechnical University
Shuisheng Hou: Chinese Academy of Agricultural Sciences
Yu Jiang: Northwest A&F University

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the selection signatures using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, the phenotypes are fine-mapped based on resequencing of 1026 ducks from an F2 segregating population generated by wild × domestic crosses. Interestingly, the two key economic traits of Pekin duck are associated with two selective sweeps with fixed mutations. A novel intronic insertion most possibly leads to a splicing change in MITF accounted for white duck down feathers. And a putative long-distance regulatory mutation causes continuous expression of the IGF2BP1 gene after birth which increases body size by 15% and feed efficiency by 6%. This study provides new insights into genotype–phenotype associations in animal research and constitutes a promising resource on economically important genes in fowl.

Date: 2018
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DOI: 10.1038/s41467-018-04868-4

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