Dissecting the mammary gland one cell at a time

Simona Cristea and Kornelia Polyak ()
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Simona Cristea: Dana-Farber Cancer Institute
Kornelia Polyak: Dana-Farber Cancer Institute

Nature Communications, 2018, vol. 9, issue 1, 1-3

Abstract: Abstract Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages.

Date: 2018
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DOI: 10.1038/s41467-018-04905-2

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