Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

Guiyang Zhang, Xinle Li, Qiaobo Liao, Yanfeng Liu, Kai Xi (), Wenyu Huang () and Xudong Jia ()
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Guiyang Zhang: Nanjing University
Xinle Li: Iowa State University
Qiaobo Liao: Nanjing University
Yanfeng Liu: Nanjing University
Kai Xi: Nanjing University
Wenyu Huang: Iowa State University
Xudong Jia: Nanjing University

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcumin derivatives (PEG-CCM) and amine-functionalized COFs (APTES-COF-1) for in vitro and in vivo drug delivery. The real-time fluorescence response shows efficient tracking of the COF-based materials upon cellular uptake and anticancer drug (doxorubicin (DOX)) release. Notably, in vitro and in vivo studies demonstrate that PEG-CCM@APTES-COF-1 is a smart carrier for drug delivery with superior stability, intrinsic biodegradability, high DOX loading capacity, strong and stable fluorescence, prolonged circulation time and improved drug accumulation in tumors. More intriguingly, PEG350-CCM@APTES-COF-1 presents an effective targeting strategy for brain research. We envisage that PEG-CCM@APTES-COF-1 nanocomposites represent a great promise toward the development of a multifunctional platform for cancer-targeted in vivo drug delivery.

Date: 2018
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DOI: 10.1038/s41467-018-04910-5

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