FABP4 as a key determinant of metastatic potential of ovarian cancer

Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez-Aguayo, Michael McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle A. Tran, Alejandro Villar-Prados, Guillermo Armaiz Pena, Ragini Kondetimmanahalli, Ryan Nini, Pranavi Koppula, Prahlad Ram, Jinsong Liu, Gabriel Lopez-Berestein, Keith Baggerly, Livia Eberlin and Anil K. Sood ()
Additional contact information
Kshipra M. Gharpure: The University of Texas MD Anderson Cancer Center
Sunila Pradeep: The University of Texas MD Anderson Cancer Center
Marta Sans: The University of Texas at Austin
Rajesha Rupaimoole: Harvard Medical School
Cristina Ivan: The University of Texas MD Anderson Cancer Center
Sherry Y. Wu: The University of Texas MD Anderson Cancer Center
Emine Bayraktar: The University of Texas MD Anderson Cancer Center
Archana S. Nagaraja: The University of Texas MD Anderson Cancer Center
Lingegowda S. Mangala: The University of Texas MD Anderson Cancer Center
Xinna Zhang: The University of Texas MD Anderson Cancer Center
Monika Haemmerle: Institute of Pathology
Wei Hu: The University of Texas MD Anderson Cancer Center
Cristian Rodriguez-Aguayo: The University of Texas MD Anderson Cancer Center
Michael McGuire: The University of Texas MD Anderson Cancer Center
Celia Sze Ling Mak: The University of Texas MD Anderson Cancer Center
Xiuhui Chen: The University of Texas MD Anderson Cancer Center
Michelle A. Tran: The University of Texas MD Anderson Cancer Center
Alejandro Villar-Prados: The University of Texas MD Anderson Cancer Center
Guillermo Armaiz Pena: Ponce Health Sciences University
Ragini Kondetimmanahalli: The University of Texas at Austin
Ryan Nini: The University of Texas MD Anderson Cancer Center
Pranavi Koppula: The University of Texas MD Anderson Cancer Center
Prahlad Ram: The University of Texas MD Anderson Cancer Center
Jinsong Liu: The University of Texas MD Anderson Cancer Center
Gabriel Lopez-Berestein: The University of Texas MD Anderson Cancer Center
Keith Baggerly: The University of Texas MD Anderson Cancer Center
Livia Eberlin: The University of Texas at Austin
Anil K. Sood: The University of Texas MD Anderson Cancer Center

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive potential of lesions can influence the outcome of these primary surgeries. Here, we explored the underlying mechanisms that could increase metastatic potential in ovarian cancer. We discovered that FABP4 (fatty acid binding protein) can substantially increase the metastatic potential of cancer cells. We also found that miR-409-3p regulates FABP4 in ovarian cancer cells and that hypoxia decreases miR-409-3p levels. Treatment with DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA inhibited tumor progression in mouse models. With RPPA and metabolite arrays, we found that FABP4 regulates pathways associated with metastasis and affects metabolic pathways in ovarian cancer cells. Collectively, these findings demonstrate that FABP4 is functionally responsible for aggressive patterns of disease that likely contribute to poor prognosis in ovarian cancer.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-04987-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04987-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-04987-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().