2D transition metal dichalcogenides with glucan multivalency for antibody-free pathogen recognition

Tae Woog Kang, Juhee Han, Sin Lee, In-Jun Hwang, Su-Ji Jeon, Jong-Min Ju, Man-Jin Kim, Jin-Kyoung Yang, Byoengsun Jun, Chi Ho Lee, Sang Uck Lee () and Jong-Ho Kim ()
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Tae Woog Kang: Hanyang University
Juhee Han: Hanyang University
Sin Lee: Hanyang University
In-Jun Hwang: Hanyang University
Su-Ji Jeon: Hanyang University
Jong-Min Ju: Hanyang University
Man-Jin Kim: Hanyang University
Jin-Kyoung Yang: Hanyang University
Byoengsun Jun: Hanyang University
Chi Ho Lee: Hanyang University
Sang Uck Lee: Hanyang University
Jong-Ho Kim: Hanyang University

Nature Communications, 2018, vol. 9, issue 1, 1-10

Abstract: Abstract The ability to control the dimensions and properties of nanomaterials is fundamental to the creation of new functions and improvement of their performances in the applications of interest. Herein, we report a strategy based on glucan multivalent interactions for the simultaneous exfoliation and functionalization of two-dimensional transition metal dichalcogenides (TMDs) in an aqueous solution. The multivalent hydrogen bonding of dextran with bulk TMDs (WS2, WSe2, and MoSe2) in liquid exfoliation effectively produces TMD monolayers with binding multivalency for pathogenic bacteria. Density functional theory simulation reveals that the multivalent hydrogen bonding between dextran and TMD monolayers is very strong and thermodynamically favored (ΔEb = −0.52 eV). The resulting dextran/TMD hybrids (dex-TMDs) exhibit a stronger affinity (Kd = 11 nM) to Escherichia coli O157:H7 (E. coli) than E. coli-specific antibodies and aptamers. The dex-TMDs can effectively detect a single copy of E. coli based on their Raman signal.

Date: 2018
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DOI: 10.1038/s41467-018-04997-w

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